Peptide · Vial
Verified recordBPC 157
$9010mg
An experimental peptide best known for early research into tissue repair, tendon injury and wound response.
Current batchBPC 004-012
Published result99.2% reported purity
EternaGen / MOTS 005-021Peptide · Research use only
MOTS-c
From CA$200CAD
A peptide made inside mitochondria and studied for its connection to energy, exercise and metabolic stress.
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MOTS-c, clearly explained.
A peptide made inside mitochondria and studied for its connection to energy, exercise and metabolic stress.
Overview
Small human studies have measured the MOTS-c that our bodies produce naturally. Research that actually administers MOTS-c has largely been limited to cells and animals, so those are two very different evidence questions.
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial 12S rRNA. Research focuses on endogenous mitochondrial signalling, metabolic stress and exercise biology.- Format
- Pen
- Available strengths
- 10mg · 40mg
- Batch
- MOTS 005-021
- Purity
- 99.0%
Research at a glanceTranslational and preclinical evidence; administered human-drug evidence absent
Reviewed 23 July 2026View research context Specifications
Product details
- Sequence / identity
- MRWQEMGYIFYPRKLR
- Molecular formula
- Confirm in batch record
- Molecular weight
- 2174.6 g/mol
- Storage and handling
- Refer to the batch record for the verified storage and handling specification.
Batch documentationVerified record available
Review the analytical record connected to this exact batch.
- Batch
- MOTS 005-021
- Purity
- 99.0%
Important research-use boundary
Health Canada lists the named compound or components among unauthorized injectable drugs identified in the Canadian market. A research-use label does not make an unauthorized product suitable or legal for personal use.
Explore the research
What has been studied?
Keep the context attached
Check what was studied, what researchers observed, and the limitation attached to each finding.
Question 01
Exercise biology
Small human sampling studies examine whether acute exercise changes endogenous MOTS-c in muscle or circulation.
Evidence so far: Translational biomarker researchQuestion 02
Metabolic stress
Cell and mouse studies investigate glucose handling, skeletal-muscle metabolism and stress adaptation.
Evidence so far: Preclinical evidenceQuestion 03
Age-related physical capacity
Mouse experiments report changes in physical performance; this has not been established as a human treatment effect.
Evidence so far: Animal evidence onlyProposed mechanism
How researchers are investigating the mechanism.
Cell and animal work suggests MOTS-c can respond to metabolic stress and influence nuclear gene expression and energy-related pathways. Human sampling studies measure endogenous MOTS-c; they do not test an administered MOTS-c product.
Study records
What was studied—and what was not.
See what researchers tested, what they observed and the limitation attached to each result.
Study 01Mechanistic animal studies plus exercise sampling in 10 young men
- What researchers saw
- The study reported exercise-associated endogenous MOTS-c changes alongside effects in mouse models.
- Why that is not the whole story
- The human component was not a therapeutic trial and did not administer MOTS-c.
Study 02FDA review of MOTS-c-related bulk substances
- What researchers saw
- FDA reported no identified human exposure data for administered MOTS-c drug products.
- Why that is not the whole story
- Endogenous peptide measurements cannot establish the safety of an administered product.
Evidence gaps
What remains unknown?
- Human pharmacokinetics, dose-response, efficacy and route-specific safety for administered MOTS-c are not established.
- Assays for endogenous MOTS-c and an external research material answer different questions.
- Long-term immunogenicity and peptide-impurity risks remain insufficiently characterized.
Primary sources
Check the original sources.
- Primary translational studyReynolds et al. MOTS-c, exercise and age-dependent physical decline. Nat Commun. 2021. PMID 33473109.
- Regulatory safety reviewU.S. FDA. MOTS-c bulk-substance safety considerations.
- Canadian public advisoryHealth Canada. Advisory on unauthorized injectable peptides, including MOTS-C. 2026.
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